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Mitts was born in Cincinnati, Ohio in 1978. She attended St. Ursula Academy in Cincinnati, where she played high school soccer. She received an athletic scholarship to attend the University of Florida in Gainesville, Florida, and played for coach Becky Burleigh's Florida Gators women's soccer team in National Collegiate Athletic Association (NCAA) competition from 1996 to 1999.
Mitts was part of the defensive line that helped the Gators win their first-ever NCAA Women's Soccer Championship in 1998. She was named a third-team All-American in 1998 and a first-team All-American in 1999, and became the Gators' all-time record holder in appearances (95), starts (94), and minutes played (7,547). She graduated from the University of Florida with a bachelor's degree in advertising in 2000.
Straight out of college, Mitts played for Tampa Bay Extreme of W-League in 2000 while waiting for the launch of the new Women's United Soccer Association league.
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Mitts returned to W-League in 2005, playing sparingly for Central Florida Krush while splitting her time between the United States Women's National Team. She appeared in four games (360 minutes).
Upon the introduction of Women's Professional Soccer, Mitts and fellow USWNT players Angela Hucles and Kristine Lilly were allocated to Boston Breakers on September 16, 2008. In the inaugural 2009 Women's Professional Soccer season, Mitts appeared in nineteen games (all starts, 1,631 minutes) and added an assist. After the season, the Boston Breakers declared Mitts a free agent.
On October 14, 2009, Mitts signed with 2010 WPS expansion team Philadelphia Independence, marking her return to play professional soccer in Philadelphia following the demise of the WUSA's Charge.
For the 2011 season of WPS, she is playing right defensive back for the Atlanta Beat.
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