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Melis has played for the Netherlands national team since 2005. She played for the Netherlands in the 2007 FIFA Women's World Cup qualifying rounds and the UEFA Women's Euro 2009 finals.
She was the Damallsvenskan top-scorer in 2010 and 2011,playing for LdB Malmö.
Manon scored 4 goals in the 6-0 won UEFA Women's EURO 2013 qualification opening match for The Netherlands against Serbia on 21 September 2011, stating: "It is a great feeling to score four goals, I had never done that before for the national team"
In November 2011 she announced she was moving from Malmö to Sky Blue FC. In her last match she helped LdB secure a spot in Champions League quarterfinals with a goal.
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